Organooxygen compounds
Medchemexpress LLC DC-BPi-11 hydrochloride | 00-00-0 | 97.0% | 433.95 g·mol⁻¹ | C20H24ClN5O2S | 5 MG
DC-BPi-11 hydrochloride is a small-molecule BPTF inhibitor supplied as a hydrochloride salt in powder form for research use. It has demonstrated inhibition of leukemia cell proliferation and a reported IC50 of approximately 698 nM, with handling and storage guidance provided for both solid and solution states.
- Inhibitor of bromodomain PHD finger transcription factor (BPTF).
- Reported IC50 ≈ 698 nM.
- Powder hydrochloride salt form.
- Molecular formula C20H24ClN5O2S.
- Molecular weight 433.95 g·mol⁻¹.
- Purity 97.0%.
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Available as a 5 mg sample pack.
Medchemexpress LLC SCH-23390 (hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 100 MG
SCH-23390 (hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 100 MG
Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 100.0% | 362.30 | 50 MG
Clemizole hydrochloride is an H1 histamine receptor antagonist that has been shown to substantially inhibit HCV replication. It also acts as an inhibitor of the TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, while its EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication in cell culture.
- Suppresses NS4B's RNA binding.
- Offers minimal host cell toxicity.
- Functions as a novel inhibitor of TRPC5 channels.
- Efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range.
- Exhibits six-fold selectivity for TRPC5 over TRPC4β.
- Displays almost 10-fold selectivity over TRPC3 and TRPC6.
Medchemexpress LLC Leelamine hydrochloride | 16496-99-4 | 98.1% | 321.93 | 10 MG
Leelamine hydrochloride is a tricyclic diterpene molecule extracted from the bark of pine trees. It acts as a cannabinoid receptor type 1 (CB1) agonist and an inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, functioning independently of androgen receptor status. It also suppresses the transcriptional activity of the androgen receptor, which regulates fatty acid synthesis.
- Cannabinoid receptor type 1 (CB1) agonist
- Inhibits SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells
- Suppresses transcriptional activity of androgen receptor
- Extracted from the bark of pine trees
Medchemexpress LLC PhiKan 083 hydrochlo | 1050480-30-2 | 99.3% | 274.79 | 10 MG
PhiKan 083 hydrochloride is a carbazole derivative that functions as a p53 Y220C stabilizer. It binds to the surface cavity of the Y220C (a p53 mutant) with a Kd of 167 μM and demonstrates a relative binding affinity (Kd) of 150 μM in Ln229 cells. This compound has been shown to slow down the thermal denaturation rate of p53 Y220C.
- Binds to the surface cavity of p53 Y220C mutant.
- Stabilizes p53 Y220C.
- Exhibits a Kd of 167 μM for p53 Y220C.
- Shows a relative binding affinity of 150 μM in Ln229 cells.
- Slows the thermal denaturation rate.
- Reduces cell viability of engineered Ln229 cell variants.
- Enhances pro-apoptotic activity in Ln229 cells when combined with NSC 123127.
Medchemexpress LLC Leelamine hydrochloride | 16496-99-4 | 98.1% | 321.93 | 25 MG
Leelamine hydrochloride is a tricyclic diterpene molecule extracted from the bark of pine trees. It acts as a cannabinoid receptor type 1 (CB1) agonist and an inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells. Its activity is not affected by androgen receptor status, and it suppresses the transcriptional activity of the androgen receptor.
- Tricyclic diterpene molecule
- Extracted from the bark of pine trees
- Cannabinoid receptor type 1 (CB1) agonist
- Inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells
- Suppresses transcriptional activity of androgen receptor
- Appearance: solid
- Color: white to off-white
- For research use only
Medchemexpress LLC Viloxazine hydrochloride | 35604-67-2 | MFCD00661100 | 98.9% | 273.75 g/mol | C13H20ClNO3 | 50MG
Viloxazine hydrochloride is a research-grade small molecule used as a selective norepinephrine transporter (NET) inhibitor and a modulator of serotonin (5-HT) receptors. Presented as the hydrochloride salt (CAS 35604-67-2) and supplied for preclinical laboratory use, it is commonly employed as a tool compound in studies of norepinephrine and serotonin signaling and in ADHD-related research.
- Research-grade hydrochloride salt with defined purity for laboratory use.
- Selective norepinephrine transporter inhibitor activity (IC50 = 0.26 μM).
- Modulates 5-HT receptors, including 5-HT2B antagonist and 5-HT2C agonist actions.
- Available in small pack sizes suitable for assays, including a 50 mg pack.
- Provided with molecular and analytical data to support traceability and reproducibility.
Medchemexpress LLC Alosetron hydrochloride | 122852-69-1 | MFCD03453647 | 99.6% | 10 MG
Alosetron hydrochloride is a potent, selective 5-HT3 receptor antagonist provided for research use in studies of irritable bowel syndrome and visceral nociception. It is supplied as a high-purity solid and is also available as ready-to-use 10 mM solutions for laboratory assays.
- Potent and selective 5-HT3 receptor antagonist.
- Used in research on diarrhea-predominant irritable bowel syndrome and visceral nociception.
- High purity suitable for analytical and in vitro applications.
- Available as a solid and as pre-made 10 mM solutions for convenience.
- Characterization includes CAS 122852-69-1 and molecular weight 330.81 g/mol.
Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | 99.9% | 835.82 g/mol | C42H52Cl2N8O6 | 10MG
Ravidasvir hydrochloride is a research-grade small-molecule inhibitor of the hepatitis C virus NS5A protein, supplied as the hydrochloride salt for laboratory studies. It exhibits potent, pan-genotypic antiviral activity and is provided with high purity and supporting documentation for use in biochemical and cellular assays.
- Pan-genotypic NS5A inhibitor with potent antiviral activity.
- High purity (99.9%) suitable for research applications.
- Supplied as a hydrochloride salt for improved solubility handling.
- Recommended storage conditions provided to preserve stability.
- Includes product datasheet and safety data sheet for lab use.
Medchemexpress LLC CZC-54252 hydrochloride | 1784253-05-9 | 98.4% | 5 MG
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50 values of 1.28 nM for wild-type LRRK2 and 1.85 nM for G2019S LRRK2. This compound can attenuate G2019S LRRK2-induced human neuronal injury with an EC50 of approximately 1 nM, exhibiting neuroprotective activity.
- Potent and selective LRRK2 inhibitor
- Attenuates G2019S LRRK2-induced human neuronal injury
- Exhibits neuroprotective activity
- Molecular weight: 541.45
- Chemical formula: C22H26Cl2N6O4S
- Appearance: Solid
- Color: Light yellow to orange
- Recommended storage: 4°C, sealed, away from moisture
Medchemexpress LLC CCG258208 hydrochloride | 98.1% | 488.94 | 1 MG
CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM). It exhibits 230-fold selectivity over GRK5 and more than 2500-fold selectivity over GRK1, PKA, and ROCK1. This compound can be utilized in heart failure research.
- Potent and selective GRK2 inhibitor (IC50=30 nM).
- Exhibits 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1.
- Applicable in heart failure research.
- Significant improvement in βAR-stimulated contractility in mouse cardiomyocytes at concentrations as low as 0.1 μM.
- Superior half-life in vivo with total plasma drug levels exceeding the GRK2 IC50 for seven hours after a single intraperitoneal administration of 10 mg/kg in CD-1 mice.
Medchemexpress LLC Flavoxate hydrochloride | 3717-88-2 | 99.7% | 250 MG
Flavoxate hydrochloride is the analytical standard of Flavoxate (hydrochloride), intended for research and analytical applications. It is a potent and competitive phosphodiesterase (PDE) inhibitor, an antispasmodic agent, and a muscarinic mAChR antagonist. It exhibits moderate calcium antagonistic activity and a local anesthetic effect. This product can be used for the research of overactive bladder (OAB) and lower urinary tract infections.
- Analytical standard for research and analytical applications.
- Potent and competitive phosphodiesterase (PDE) inhibitor.
- Antispasmodic agent.
- Muscarinic mAChR antagonist.
- Shows moderate calcium antagonistic activity.
- Possesses local anesthetic effect.
- Applicable for research on overactive bladder (OAB) and lower urinary tract infections.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Ladostigil hydrochlo 5mg | 209394-18-3 | 5MG
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with IC50s of 37 1 and 31 8 M for MAO-B and AChE respectively Ladostigil hydrochloride exhibits neuroprotective antioxidant and anti-inflammatory activities Ladostigil can be used for the research of depression and Alzheimer s disease[1 [2 Ladostigil (hydrochloride) is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity and reduces TXNIP mRNA and protein levels in INS-1 cells.
- Lowers glucagon secretion in TC1-6 cells and decreases glucagon secretion and action in vivo.
- Reduces glucagon-induced glucose output from primary hepatocytes and blocks hepatic glucose output in vivo.
- Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice.
- Orally bioavailable.
- Well-tolerated in male C57BL/6J mice.
Medchemexpress LLC Buspirone hydrochloride | 33386-08-2 | 99.99% | 1 ML
Buspirone hydrochloride is a 5-HT1A receptor agonist. It can be used for anxiety and depression research.
- 5-HT1A receptor agonist
- Can be used for anxiety and depression research
- Has cytotoxic effect in lymphocytes (0-400 μg/mL; 6 hours)
- Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG) (0-180 μg/mL; 0-3 hours; lymphocytes)
- Reduces anxiety/depression behaviors in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
- Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
- Reduces TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon in C57BL/6N mice
- Reduces the IS- or EC-induced gut proteobacteria population in C57BL/6N mice